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KMID : 1036420150080020065
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대한치의학회 영문학회지
2015 Volume.8 No. 2 p.65 ~ p.73
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Effect of Intermittent Parathyroid Hormone Administration on the Microstructure of Jaw Bone in the Ovariectomized Rats
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Kang Kang-Su
Kim Kun-Hyoung
Heo Hyun-A
Park Su-Hyun
Pyo Sung-Woon
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Abstract
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Purpose: Parathyroid hormone (PTH) therapy has drawn attention, as an alternative to anti-resorptive drugs since PTH accelerates bone density by anabolic action. The purpose of this study was to identify the effect of intermittent PTH administration on jaw bones of rat undergone bilateral ovariectomy.
Materials and Methods: Nine female Sprague-Dawley rats were divided into three groups. PTH group was ovariectomized (OVX) to induce osteoporosis and PTH 30 μg/kg was administered 1 week after the surgery. In OVX group, ovariectomy was performed and only vehicle was administered by subcutaneous injection 3 times per week. Control group was subjected to sham surgery. The animals were sacrificed 8 weeks after the surgery and specimens were obtained from ilium and upper and lower jaw bones. Histological investigation was carried out by using an optical microscope and micro-computed tomography was taken to examine structural property changes in each bone sample.
Result: In the ilium, the bone volume ratio (bone volume/total volume, BV/TV) of PTH, OVX and control groups was 53.75%±7.57%, 50.61%±12.89%, 76.20%±5.92% (P=0.061) and bone mineral density (BMD) was 1.12±0.09, 0.88±0.48, 1.38±0.07 g/cm3 (P=0.061). In the mandible, BV/TV of PTH, OVX and control groups was 64.60%±12.17%, 58.26%±9.63%, 67.54%±14.74% (P=0.670) and BMD was 1.21±0.17, 1.19±0.13, 1.27±0.18 g/cm3 (P=0.587). In the maxilla, BV/TV of PTH, OVX and control groups was 61.19%±8.92%, 52.50%±11.22%, 64.60%±12.17% (P=0.430) and BMD was 1.20±0.11, 1.11±0.16, 1.21±0.17 g/cm3 (P=0.561). No statistically significant difference was found in any variables in all groups. Histological observation revealed that the ilium in OVX group demonstrated sparsely formed trabecular bones compared with other groups. However, upper and lower trabecular bones did not present significant differences.
Conclusion: Intermittent administration of PTH appears to affect the microstructure of rat jaw bones, but statistical significance was not found. However, the measurements in this study partly implicated the possible anabolic effect of PTH in vivo.
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KEYWORD
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Bone density, Osteoporosis, Ovariectomy, Parathyroid hormone
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